An endothelial RNA splicing atlas catalogs effects of IL-1β and identifies an alternative PROCR isoform with genetic links to pleiotropic vascular disease

To inform vascular disease processes attributable to alternative splicing, we modeled inflammation in endothelial cell lines. We found that alternative promoters were key regulators of transcript diversity, especially for metabolic genes. Using sQTL mapping, we also identified splicing events associated with vascular disease risk alleles, including PROCR.