DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations

Underrepresentation of admixed populations limits equitable polygenic risk score (PRS) application. We developed DiscoDivas, a genetic-distance-assisted framework that interpolates PRSs across an ancestry continuum. By harmonizing multiple fine-tuned models without ancestry-specific switching, DiscoDivas improves PRS predictive performance, especially for admixed individuals.