Autor: Clinical genetics
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Rare gene variants may multiply Alzheimer’s disease risk
Alzheimer’s disease is the most common form of dementia worldwide, and its development is influenced by a combination of genetic and environmental factors. In recent years, the PLCG2 gene and its encoded enzyme, PLCγ2, have emerged as some of the most …
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Advanced genetic testing opens new treatment options for nearly one in three cancer patients, study finds
A new study from London Health Sciences Centre Research Institute (LHSCRI) shows that expanded genetic testing can help match cancer patients with more personalized treatment options, with nearly one in three found eligible for therapies not typically …
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What is sudden adult death syndrome?
When Mark Hughes, the former Manchester United and Wales manager, lost his 38-year-old son, an inquest found the cause was sudden adult death syndrome, or SADS.
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What is sudden adult death syndrome?
When Mark Hughes, the former Manchester United and Wales manager, lost his 38-year-old son, an inquest found the cause was sudden adult death syndrome, or SADS.
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New approach opens rare immune cells to genetic risk research
Much of how genetic risk leads to disease has remained hidden. In many cases, genetic variants linked to disease do not act on nearby genes along the chromosome. Instead, they influence genes located far away along the DNA sequence. This happens becaus…
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New approach opens rare immune cells to genetic risk research
Much of how genetic risk leads to disease has remained hidden. In many cases, genetic variants linked to disease do not act on nearby genes along the chromosome. Instead, they influence genes located far away along the DNA sequence. This happens becaus…
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Genome analysis uncovers candidate genes for hereditary breast and ovarian cancer
Breast cancer is the most common form of cancer among women in Germany: Around 1 in 8 women will develop it during their lifetime. In around 5% to 10% of cases, the condition is caused by a hereditary predisposition. Thirteen risk genes have currently …
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Genome analysis uncovers candidate genes for hereditary breast and ovarian cancer
Breast cancer is the most common form of cancer among women in Germany: Around 1 in 8 women will develop it during their lifetime. In around 5% to 10% of cases, the condition is caused by a hereditary predisposition. Thirteen risk genes have currently …
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In vivo CRISPR screen identifies gene edits that strengthen CAR-T therapy against solid tumors
For patients with blood cancers like leukemia and lymphoma, the immunotherapy known as CAR-T cell therapy can be lifesaving. Doctors remove a patient’s immune cells, called T cells, engineer them in the lab to better recognize and attack cancer, and in…
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In vivo CRISPR screen identifies gene edits that strengthen CAR-T therapy against solid tumors
For patients with blood cancers like leukemia and lymphoma, the immunotherapy known as CAR-T cell therapy can be lifesaving. Doctors remove a patient’s immune cells, called T cells, engineer them in the lab to better recognize and attack cancer, and in…