MARRVEL-MCP: An agentic interface for Mendelian disease discovery via tool-augmented context engineering

Everton et al. develop MARRVEL-MCP, a natural-language interface that enables large language models to use 44 genomic tools for rare disease variant interpretation. With tool access, small models (3B–20B) matched or outperformed larger models without tools, highlighting structured context engineering in genomic reasoning.