Autor: Zachary Everton, Jorge Botas, Seon Young Kim, Lin Yao, Zhandong Liu, Hyun-Hwan Jeong
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MARRVEL-MCP: An agentic interface for Mendelian disease discovery via tool-augmented context engineering
Everton et al. develop MARRVEL-MCP, a natural-language interface that enables large language models to use 44 genomic tools for rare disease variant interpretation. With tool access, small models (3B–20B) matched or outperformed larger models without t…
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MARRVEL-MCP: An agentic interface for Mendelian disease discovery via tool-augmented context engineering
Everton et al. develop MARRVEL-MCP, a natural-language interface that enables large language models to use 44 genomic tools for rare disease variant interpretation. With tool access, small models (3B–20B) matched or outperformed larger models without t…