All of Us Research Program year in review: 2025

The All of Us Research Program1 released its first genomic dataset (Curated Data Repository version 5 [CDRv5]) of almost 100,000 participants in 2022. Since then, All of Us has continued to expand the scale of its genomic offerings, releasing short-read whole genome sequencing (srWGS) for over 240,000 participants in 2023 (CDRv7) and for over 400,000 participants in 2025 (CDRv8). These genomic data are linked to a rich collection of phenotypic data encompassing electronic health records (EHRs), participant-provided information (PPI), and wearables, enabling a broad spectrum of research across diverse domains.