Autor: Hamish A.J. MacGregor, Jamie R. Blundell, Douglas F. Easton
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Shared inheritance reveals landscape of somatic and germline cancer risk in TP53
MacGregor et al. distinguish germline from somatic TP53 variants in 469,391 individuals using shared haplotype segments. Classic Li-Fraumeni alleles detected in healthy blood appear to be mostly somatic clonal expansions conferring largely hematologica…
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Shared inheritance reveals landscape of somatic and germline cancer risk in TP53
MacGregor et al. distinguish germline from somatic TP53 variants in 469,391 individuals using shared haplotype segments. Classic Li-Fraumeni alleles detected in healthy blood appear to be mostly somatic clonal expansions conferring largely hematologica…