Autor: Harkeran K Jandu
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Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes
Chronic, low-grade systemic inflammation is a polygenic trait captured with the INFLA-score, a composite of C-reactive protein, platelet count, leukocyte count, and granulocyte-to-lymphocyte ratio. We derived a polygenic risk score from the INFLA-score (iPRS) in a multi-ancestry population from the UK Biobank (n = 421,368), then evaluated and used it in a phenome-wide association study…