Autor: Kathryn A. Lawrence, Tamara Gjorgjieva, Daniel Nachun, Stephen B. Montgomery
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Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants
Standard eQTL mapping and GWAS interpretation assume that each variant acts on one gene. However, neighboring genes can exhibit “allelic proxitropy,” where regulatory effects are shared. To identify these effects, we map QTLs on expression principal co…