Autor: Marion Amujal
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Distinct host genetic determinants of HIV acquisition and disease progression: the case of classical HLA class I
HIV acquisition and disease progression appear to be influenced by largely distinct host genetic factors. Whether infection becomes established is determined shortly after mucosal or parenteral exposure, before HIV-specific CD8+ T-cell responses become…
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Beyond CCR5 and HLA: rare genetic variants in HIV acquisition and disease progression
The CCR5 locus and the HLA class I region, first identified through candidate gene studies, remain the most well-characterized host genetic factors associated with HIV acquisition and disease progression, respectively. To date, genome wide association …