Categoría: Trends in Genetics

The phenomenon of genome gigantism, defined as an organism’s haploid nuclear DNA content (C-value) exceeding 10 gigabases (Gb), has been demonstrated to exhibit a substantial degree of variability in mutational and selective processes across diverse li…

Over the past decade, the rapid expansion of large-scale data and advances in computational power have allowed machine learning (ML), especially deep learning, to reshape many areas of biological research. Evolutionary genetics and molecular evolution …

GRIN2A, a gene encoding a subunit of the N-methyl-d-aspartate (NMDA) receptor, is linked to epilepsy, language impairment, and schizophrenia, but how these associations relate to one another within individuals remains unclear. Recontacting GRIN2A carri…

Transposable elements (TEs) represent a major component of diverse genomes, can generate large-effect mutations, and affect adaptive evolution. Despite their significant role in various evolutionary processes, the regulatory mechanisms governing TE abu…

Detecting double-stranded DNA sequences typically requires enzymes to unwind and amplify the target. A new study by Yan et al. challenges this view by combining gamma peptide nucleic acid with multicomponent deoxyribozyme in droplets, achieving single-…

Circular DNA molecules that exist outside of chromosomes are common in the cells of all eukaryotes. Genes expressed from these extrachromosomal circular DNA molecules drive rapid evolution in yeasts, animals, and plants and play important roles in canc…