Categoría: Trends in Genetics

Trends in Genetics receives hundreds of presubmission inquiries each year from potential authors around the world, and although the proposed topics vary widely, they sometimes converge on various trends—some broadly transformative (hello, AI!) and othe…

Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular heterogeneity, yet traditional scRNA-seq methods primarily capture transcript ends, limiting analyses to total gene expression. Advances in isoform-resolved scRNA-s…

Pre-mRNA undergoes extensive processing during transcription by RNA polymerase II, including splicing, folding, and 3′-end cleavage and polyadenylation. In this forum, we discuss recent studies that have devised powerful sequencing methods to detect co…

The genetic code determines not only the amino acid sequences of proteins but also mRNA stability. How is this hidden message read? Hia and colleagues have now identified human DHX29 as a reader of the mRNA stability code carried by codons, providing n…