Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes

This study provides a comprehensive catalog of expression, splicing, and alternative polyadenylation QTLs in gastric tissues from Chinese individuals. Integration with gastric cancer GWAS data identified 34 susceptibility genes. Functional experiments support regulatory mechanisms involving FDPS exon 9 skipping and UBE2L3 polyadenylation.