Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease

Sun et al. conduct a multi-population transcriptome-wide association study (TWAS) of Alzheimer disease using African American, non-Hispanic White, and Hispanic participants. Integrating multi-ancestry eQTL fine-mapping with TWAS prioritizes nine disease-associated genes and demonstrates that diverse population inclusion improves fine-mapping precision and biological interpretability of genetic signals.