Response to Quinodoz and Leroy

To the Editor: We appreciate the interest of Drs. Quinodoz and Leroy in our publication. In general, we agree that further studies are required to determine how generalizable the reported findings are. That said, we believe the data reported provide compelling evidence of reduced penetrance of inherited retinal degeneration (IRD)-associated variants. We have grouped the specific concerns raised in the letter into three categories and responded to them below.