This month in The Journal

In genomic medicine, continuously updated public archives of genetic variants linked to clinical phenotypes, such as ClinVar and the Matchmaker Exchange, are essential for variant interpretation, patient diagnosis, and treatment. This form of data sharing typically does not require explicit patient consent, especially for de-identified variant-level data, but because there are no standard data sharing guidelines, clinicians, laboratories, and patients are often left uncertain about the practical boundaries and the rationale.