The structure and regulatory biology of the SST1/NBL2 macrosatellite family

Primate-specific SST1/NBL2 macrosatellites are emerging as key components of human acrocentric chromosome biology. Here, we integrate historical mapping, telomere-to-telomere assemblies, and regulatory evidence to show that SST1/NBL2 variation and transcription influence genome instability, chromatin dynamics, and the emerging roles of repeat-derived RNAs in human cells.