Etiqueta: #TrendsGen
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No bird soars in a calm: therapeutic germline gene editing
Global healthcare systems spend trillions of dollars treating inherited diseases. Therapeutic germline gene editing has the potential to fundamentally shift medicine from treatment to prevention by genetically correcting the disease mutation at the emb…
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Richer together: genetics and spirituality in public conversation
Using a conference on genetics and spirituality as a case study, this article examines strategies for engaging diverse audiences in conversations about Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and related genetic technologies….
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One million exomes identify FNIP1 as a metabolic brake
Exome sequencing of more than 1 million people uncovered dozens of genes linked to the biomarker of the body’s energy state (Hindy et al.). Rare loss-of-function variants in FNIP1, a suppressor of mitochondrial energy expenditure, were associated with …
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Hologenomic interactions promote the higher-order evolvability of phenotypic complexity
Current models for evolvability and complexity generally focus on mutational and regulatory processes in the host genome alone, limiting their ability to explain the origin, inheritance, and dynamics of many phenotypes. We describe a framework treating…