Autor: Haiqing Fu, Christophe E. Redon, Hannah M. Brenner, Michael R. Ack, Mirit I. Aladjem
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Replication origin flexibility: a tool to mitigate the hazards of excess replication
Chromosome duplication is critical for genome integrity, yet inaccurate DNA synthesis can induce DNA damage and foster structural genomic variations. Cells mitigate these risks using flexible replication initiation mechanisms responsive to changes in c…
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Replication origin flexibility: a tool to mitigate the hazards of excess replication
Chromosome duplication is critical for genome integrity, yet inaccurate DNA synthesis can induce DNA damage and foster structural genomic variations. Cells mitigate these risks using flexible replication initiation mechanisms responsive to changes in c…