Etiqueta: AmJHumGenet
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Principled measures and estimates of trait polygenicity
The “polygenicity” of traits is often invoked, sometimes quantified, but rarely defined from first principles. Here, we define polygenicity measures and argue why the definition is sensible. We estimate three measures for 36 human traits and find that …
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Principled measures and estimates of trait polygenicity
The “polygenicity” of traits is often invoked, sometimes quantified, but rarely defined from first principles. Here, we define polygenicity measures and argue why the definition is sensible. We estimate three measures for 36 human traits and find that …
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The impact of sex on the immune system explored at the single-cell level
Yazar et al. characterized sex-based immune differences at single-cell resolution using sex-differential expression (differentially expressed genes [DEGs]) and sex-stratified expression quantitative loci (eQTLs). They identified sex-biased genes and pa…
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This month in The Journal
Population cohorts have enabled the discovery of genetic variants associated with a multitude of human phenotypes. While the focus is usually on SNPs, other types of variants have been shown to be impactful, including tandem repeats (TRs). Typically, i…
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The impact of sex on the immune system explored at the single-cell level
Yazar et al. characterized sex-based immune differences at single-cell resolution using sex-differential expression (differentially expressed genes [DEGs]) and sex-stratified expression quantitative loci (eQTLs). They identified sex-biased genes and pa…
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This month in The Journal
Population cohorts have enabled the discovery of genetic variants associated with a multitude of human phenotypes. While the focus is usually on SNPs, other types of variants have been shown to be impactful, including tandem repeats (TRs). Typically, i…
-
The impact of sex on the immune system explored at the single-cell level
Yazar et al. characterized sex-based immune differences at single-cell resolution using sex-differential expression (differentially expressed genes [DEGs]) and sex-stratified expression quantitative loci (eQTLs). They identified sex-biased genes and pa…
-
This month in The Journal
Population cohorts have enabled the discovery of genetic variants associated with a multitude of human phenotypes. While the focus is usually on SNPs, other types of variants have been shown to be impactful, including tandem repeats (TRs). Typically, i…
-
Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles
Polymorphism of human leukocyte antigens (HLA) guides differential immune responses to infection. We analyze how HLA evolved across the distinct environments of Papua New Guinea. We find that HLA diversity correlates with altitude and that naturally se…
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Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles
Polymorphism of human leukocyte antigens (HLA) guides differential immune responses to infection. We analyze how HLA evolved across the distinct environments of Papua New Guinea. We find that HLA diversity correlates with altitude and that naturally se…