Etiqueta: #TrendsGen
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Beyond housekeeping: snRNA diversity, regulation, and human disease
Recent analyses challenge the long-standing view of small nuclear RNAs (snRNAs) as largely uniform and functionally interchangeable molecules. Their genes undergo lineage-specific expansions and losses, and in humans, individual loci display striking s…
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Co-transcriptional splicing: Distinct phases, mutual benefits, and basis for nuclear architecture
Co-transcriptional splicing is the process by which splicing takes place on nascent RNA before transcription terminates. Imaging- and sequencing-based technologies have revealed co-transcriptional splicing in eukaryotes, but more interesting questions …
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Viral tags as keys to advancing invasion genomics
Invasion genetics and genomics have greatly advanced the study of biological invasions, yet they often fail to resolve population dynamics at the fine spatiotemporal scales characteristic of most invasions. We propose shifting the focus away from the h…
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The SMN locus in the T2T era: Structure, gene conversion, and clinical implications
Long-read sequencing, paralog-aware variant calling, and telomere-to-telomere (T2T) human genome assemblies now enable the resolution of copy-, haplotype-, and nucleotide-level complexities in segmentally duplicated loci, which were previously inaccess…
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From mobile DNA to medicine: Fusion Conference highlights the therapeutic potential of endogenous retroelements in human disease
Endogenous retroelements (EREs) are a subset of transposable elements (TEs) that mobilize via an RNA intermediate. They include retrotransposable elements such as long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs…
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From mobile DNA to medicine: Fusion Conference highlights the therapeutic potential of endogenous retroelements in human disease
Endogenous retroelements (EREs) are a subset of transposable elements (TEs) that mobilize via an RNA intermediate. They include retrotransposable elements such as long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs…